Remnants of an ancient metabolism without phosphate
Goldford, J.E., Hartman, H., Smith, T.F., & Segrè, D. Remnants of an ancient metabolism without phosphate. Cell. 2017 Mar 9; 168(6): 1126-1134
CV
Education
- Ph.D., Bioinformatics (Advisor: Daniel Segrè), Boston University, 2018
- M.S., Microbial Engineering (Advisor: Igor Libourel), University of Minnesota, 2013
- B.S., Chemistry & Biochemistry, University of Minnesota, 2010
Professional Appointments
- Research Scientist, Caltech, 2023-Present
- Physics of Living Systems Fellow, MIT, 2020-2023
- Scientist, Agios Pharmaceuticals, 2018-2020
Selected Publications
Modern views of ancient metabolic networks
Goldford, J.E., & Segrè, D. Modern views of ancient metabolic networks. Current Opinion in Systems Biology. 2018 Apr; (8) 117-124
Emergent simplicity in microbial community assembly
Goldford, J.E., Lu, N., Bajic, D., Estrela, S., Tikhonov M., Gorostiaga, A., Segrè, D., Mehta, P., & Sanchez, A. Emergent simplicity in microbial community assembly. Science. 2018 Aug; (361) 469-74
Environmental boundary conditions for the origin of life converge to an organo-sulfur metabolism
Goldford, J.E., Hartman, H., Marsland R., & Segrè, D. Environmental boundary conditions for the origin of life converge to an organo-sulfur metabolism. Nature Ecology & Evolution. 2019 Nov; (3)1715-1724
Protein cost minimization promotes the emergence of coenzyme redundancy
Goldford, J.E., George, A.B., Flamholz, A.I., & Segrè, D. Protein cost minimization promotes the emergence of coenzyme redundancy. PNAS. 2022 Mar; 119 (14) e2110787119
Continuity between ancient geochemistry and modern metabolism enabled by non-autocatalytic purine biosynthesis
Goldford, J.E., Smith, H.B., Longo, L.M. Wing, B., & McGlynn, S.M.. Continuity between ancient geochemistry and modern metabolism enabled by non-autocatalytic purine biosynthesis. (*co-corresponding author). bioRxiv. 2022. doi: https://doi.org/10.1101/2022.10.07.511356 (submitted)